Experimental chronic sleep fragmentation alters seizure susceptibility and brain levels of interleukins 1β and 6

Brain hyperexcitability in sleep apnea is believed to be provoked by hypoxemia, but fragmentation can also play a significant role. Sleep trigger inflammatory mechanisms. The aim of this research was investigate the effects chronic on seizure susceptibility and brain cytokine profile. Chronic male rats with implanted EEG electrodes achieved treadmill method. Rats were randomized to: control (TC); activity (AC) (SF) group. Convulsive behavior assessed 14 days later incidence, latency time severity during 30 min following lindane administration. number duration ictal periods determined. Levels IL-1β IL-6 measured animals’ serum structures (hippocampus, thalamus cerebral cortex), separate rat cohort that underwent same protocol except Incidence seizures significantly increased, while decreased SF+L compared TC+L Seizure AC+L increased thalamus, cortex hippocampus SF AC TC groups. statistically higher only animals, thalamic or hippocampal tissue, no difference observed between It could concluded fourteen-day increases modulates production IL-6.